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Treatment for Adolescents With Depression Study (TADS) Team. Fluoxetine,

06 Dec

Adolescents suffering from Major Depressive Disorder (MDD) do well with a combination of Cognitive Behavioral Therapy and Prozac, in a randomized, controlled, multicenter, partially blinded study at Duke University Medical Center.

This multi-center, controlled, randomized, partially blinded study out of Duke University compares the efficacy of cognitive-behavioral therapy (CBT) with the selective serotonin reuptake inhibitor (SSRI) fluoxetine (Prozac) and their combination for 439 adolescents between 12 and 17 years old suffering from major depressive disorder.

Subjects were randomized into twelve weeks of either fluoxetine alone (10 to 40mg/d), CBT alone, CBT with fluoxetine, or placebo. Placebo and fluoxetine alone were administered double-blind; CBT alone and CBT with fluoxetine were administered unblinded.

The study found that, compared with placebo, the combination of fluoxetine with CBT was statistically significant (P =.001), and compared with fluoxetine alone (P =.02) and CBT alone (P =.01), treatment of fluoxetine with CBT was superior. Fluoxetine alone was a superior treatment to CBT alone (P =.01). The study concludes that the combination of fluoxetine with CBT offered the most favorable trade off between benefit and risk for adolescents with major depressive disorder.

Citation: March J, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, Burns B, DominoM, McNulty S, Vitiello B, Severe J; Treatment for Adolescents With Depression Study (TADS) Team. Fluoxetine, cognitive-behavioral therapy,and their combination for adolescents with depression: Treatment forAdolescents With Depression Study (TADS) randomized controlled trial. JAMA. 2004 Aug 18;292 (7): pages 807-20. This email address is being protected from spambots. You need JavaScript enabled to view it.
Belleruth Naparstek

Psychotherapist, author and guided imagery pioneer Belleruth Naparstek is the creator of the popular Health Journeys guided imagery audio series. Her latest book on imagery and posttraumatic stress, Invisible Heroes: Survivors of Trauma and How They Heal (Bantam Dell), won the Spirituality & Health Top 50 Books Award